禽源呼肠孤病毒诱导宿主免疫应答研究进展

doi:10.11843/j.issn.0366-6964.2017.12.004

摘要/Abstract

摘要：

禽源呼肠孤病毒是一类重要的禽类病原体，能引起感染家禽和水禽法氏囊、脾和胸腺等器官严重受损，造成免疫抑制，且易与其他病原体混合感染，极大地阻碍了全球养禽业的健康发展。天然免疫应答具有反应迅速、不针对特定抗原且作用范围广的特性，是当前免疫学和微生物学的研究热点。适应性免疫应答能够排除体内特异性抗原异物，抵抗相同病原体的再次入侵，是预防接种的免疫学基础。本文将从禽源呼肠孤病毒诱导宿主天然免疫应答和适应性免疫应答两方面，阐述此类病毒感染对宿主免疫系统的影响，以期为靶向病毒和宿主免疫反应的疫苗设计提供参考依据。

Abstract:

Avian-origin reovirus, which is a kind of important poultry and waterfowl pathogen, can cause serious damage to the bursa of Fabricius, spleen and thymus of infected birds, resulting in immunosuppression and increased susceptibility to secondary diseases that greatly hinder the healthy development of global poultry and waterfowl industry. The innate immune response is the hotspot in the field of microbiology and immunology due to its earlier and quick non-specific response against pathogens. Adaptive immune response can eliminate the intruding pathogens,and defend against reinfection of the same pathogens, which provides immunological basis for the immunization of host. In this review, we highlight the current understanding of host innate immune response and adaptive immune response induced by avian-origin reovirus and the effects of such virus infection on the host immune system. This review will provide a basis for understanding the virus-host interaction and vaccine development.

中图分类号:

池晓娟, 邵文涵, 陈吉龙, 陈月香, 王松. 禽源呼肠孤病毒诱导宿主免疫应答研究进展[J]. 畜牧兽医学报, 2017, 48(12): 2249-2257.

CHI Xiao-juan, SHAO Wen-han, CHEN Ji-long, CHEN Yue-xiang, WANG Song. The Research Advance of Host Immune Response Induced by Avian-origin Reovirus[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(12): 2249-2257.

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参考文献

[1] ZHONG L, GAO L, LIU Y, et al. Genetic and pathogenic characterisation of 11 avian reovirus isolates from northern China suggests continued evolution of virulence[J]. Sci Rep, 2016,6:35271.
[2] AYALEW L E, GUPTA A, FRICKE J, et al. Phenotypic, genotypic and antigenic characterization of emerging avian reoviruses isolated from clinical cases of arthritis in broilers in Saskatchewan, Canada[J]. Sci Rep, 2017,7(1):3565.
[3] LU H, TANG Y, DUNN P A, et al. Isolation and molecular characterization of newly emerging avian reovirus variants and novel strains in Pennsylvania, USA, 2011-2014[J]. Sci Rep, 2015,5:14727.
[4] VAN DER HEIDE L. The history of avian reovirus[J]. Avian Dis, 2000,44(3):638-641.
[5] 胡奇林, 陈少莺, 林锋强, 等. 番鸭呼肠孤病毒的鉴定[J]. 病毒学报, 2004,20(3):242-248.
HU Q L, CHEN S Y, LIN F Q, et al. The identification of muscovy duck reovirus[J]. Chinese Journal of Virology, 2004, 20(3):242-248. (in Chinese)
[6] YUN T, YU B, NI Z, et al. Isolation and genomic characterization of a classical muscovy duck reovirus isolated in Zhejiang, China[J]. Infect Genet Evol, 2013, 20:444-453.
[7] ZHU Y Q, LI C F, BI Z L, et al. Molecular characterization of a novel reovirus isolated from Pekin ducklings in China[J]. Arch Virol, 2015, 160(1):365-369.
[8] LI N, HONG T, WANG Y, et al. The pathogenicity of novel duck reovirus in Cherry Valley ducks[J]. Vet Microbiol, 2016,192:181-185.
[9] 陈少莺, 陈仕龙, 林锋强, 等. 新型鸭呼肠孤病毒的分离与鉴定[J].病毒学报, 2012, 28(3):224-230.
CHEN S Y, CHEN S L, LIN F Q, et al. The isolation and identification of novel duck reovirus[J]. Chinese Journal of Virology, 2012, 28(3):224-230. (in Chinese)
[10] 陈少莺, 陈仕龙, 林锋强, 等. 一种新的鸭病(暂名鸭出血性坏死性肝炎)病原学研究初报[J]. 中国农学通报, 2009,25(16):28-31.
CHEN S Y, CHEN S L, LIN F Q, et al. The primary study of pathogen of duck hemorrhagic-necrotic hepatitis[J]. Chinese Agricultural Science Bulletin, 2009, 25(16):28-31.(in Chinese)
[11] CHEN Z, ZHU Y, LI C, et al. Outbreak-associated novel duck reovirus, China, 2011[J]. Emerg Infect Dis, 2012,18(7):1209-1211.
[12] OLSON N O. Transmissible synovitis of poultry[J]. Lab Invest, 1959, 8:1384-1393.
[13] GAUDRY D, CHARLES J M, TEKTOFF J. A new disease expressing itself by a viral pericarditis in Barbary ducks[J]. C R Acad Sci Hebd Seances Acad Sci D, 1972, 274(21):2916-2919.
[14] ZHANG Y, GUO D, LIU M, et al. Characterization of the sigmaB-encoding genes of muscovy duck reovirus:sigmaC-sigmaB-ELISA for antibodies against duck reovirus in ducks[J]. Vet Microbiol, 2007, 121(3-4):231-241.
[15] AKIRA S, UEMATSU S, TAKEUCHI O. Pathogen recognition and innate immunity[J]. Cell, 2006, 124(4):783-801.
[16] BOWIE A G, UNTERHOLZNER L. Viral evasion and subversion of pattern-recognition receptor signalling[J]. Nat Rev Immunol, 2008, 8(12):911-922.
[17] OUYANG J, ZHU X, CHEN Y, et al. NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription[J]. Cell Host Microbe, 2014, 16(5):616-626.
[18] WEI H, WANG S, CHEN Q, et al. Suppression of interferon lambda signaling by SOCS-1 results in their excessive production during influenza virus infection[J]. PLoS Pathog, 2014, 10(1):e1003845.
[19] QI X, LIU C, LI R, et al. Modulation of the innate immune-related genes expression in H9N2 avian influenza virus-infected chicken macrophage-like cells (HD11) in response to Escherichia coli LPS stimulation[J]. Res Vet Sci, 2017, 111:36-42.
[20] CHEN S, LUO G, YANG Z, et al. Avian Tembusu virus infection effectively triggers host innate immune response through MDA5 and TLR3-dependent signaling pathways[J]. Vet Res, 2016, 47(1):74.
[21] CHEN S, WANG L, CHEN J, et al. Avian interferon-inducible transmembrane protein family effectively restricts avian Tembusu virus infection[J]. Front Microbiol, 2017, 8:672.
[22] RUE C A, SUSTA L, CORNAX I, et al. Virulent Newcastle disease virus elicits a strong innate immune response in chickens[J]. J Gen Virol, 2011, 92(Pt4):931-939.
[23] KAMEKA A M, HADDADI S, KIM D S, et al. Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens[J]. Virology, 2014, 450-451:114-121.
[24] LOSTALÉ-SEIJO I, MARTINEZ-COSTAS J, BENAVENTE J. Interferon induction by avian reovirus[J]. Virology, 2016, 487:104-111.
[25] 黄莉,谢芝勋,蓝元喜,等. 禽呼肠孤病毒感染对SPF鸡外周血淋巴细胞中天然免疫相关基因转录的影响[J]. 畜牧兽医学报, 2017, 48(1):116-123.
HUANG L, XIE Z X, LAN Y X, et al. Effects of avian reovirus infection on transcription of innate immune genes in peripheral blood lymphocytes of SPF chickens[J]. Acta Veterinaria et Zootechnica Sinica, 2017, 48(1):116-123. (in Chinese)
[26] 黄莉, 谢芝勋, 蓝元喜,等. 禽呼肠孤病毒感染后SPF鸡关节中Toll样受体的mRNA转录水平变化[J]. 中国兽医学报, 2017, 37(3):433-437.
HUANG L, XIE Z X, LAN Y X, et al. Activated expression of toll-like receptors in joints of SPF chickens infected with avian reovirus[J]. Chinese Journal of Veterinary Science, 2017, 37(3):433-437. (in Chinese)
[27] 黄莉, 谢芝勋, 蓝元喜,等. 禽呼肠孤病毒感染后Toll样受体在SPF鸡不同器官中的表达变化[J]. 中国兽医科学, 2017, 47(2):202-206.
HUANG L, XIE Z X, LAN Y X, et al. Expression profiles of toll-like receptors in different organs of SPF chickens infected with avian reovirus[J]. Chinese Veterinary Science, 2017, 47(2):202-206. (in Chinese)
[28] LIN P Y, LIU H J, LIAO M H, et al. Activation of PI 3-kinase/Akt/NF-kappaB and Stat3 signaling by avian reovirus S1133 in the early stages of infection results in an inflammatory response and delayed apoptosis[J]. Virology, 2010, 400(1):104-114.
[29] XIE L, XIE Z, HUANG L, et al. Avian reovirus sigmaA and sigmaNS proteins activate the phosphatidylinositol 3-kinase-dependent Akt signalling pathway[J]. Arch Virol, 2016, 161(8):2243-2248.
[30] 张昆丽, 谢芝勋, 黄莉, 等. 禽呼肠孤病毒感染鸡胚成纤维细胞后IL-17, IL-18和IFN-γ mRNA转录水平的动态变化[J]. 中国兽医学报, 2015,35(3):345-349.
ZHANG K L, XIE Z X, HUANG L, et al. The dynamic change of IL-17, IL-18 and IFN-γ mRNA transcription level in chicken embryo fibroblast infected with avian reovirus[J]. Chinese Journal of Veterinary Science, 2015,35(3):345-349. (in Chinese)
[31] NEELIMA S, RAM G C, KATARIA J M, et al. Avian reovirus induces an inhibitory effect on lymphoproliferation in chickens[J]. Vet Res Commun, 2003, 27(1):73-85.
[32] 张昆丽, 谢芝勋, 黄莉, 等. 禽呼肠孤病毒感染鸡胚成纤维细胞后三种细胞因子基因mRNA转录水平的动态变化[J]. 中国兽医科学, 2014,44(8):805-810.
ZHANG K L, XIE Z X, HUANG L, et al. Dynamic changes of IL-1β, IL-6 and TNF-α mRNA levels in chicken embryo fibroblast infected with avian reovirus[J]. Chinese Veterinary Science, 2014,44(8):805-810. (in Chinese)
[33] 张昆丽, 谢芝勋, 黄莉, 等. 禽呼肠孤病毒感染对SPF鸡跗关节细胞因子mRNA转录的影响[J]. 畜牧兽医学报, 2014,45(9):1505-1511.
ZHANG K L, XIE Z X, HUANG L, et al. Effect of avian reovirus infection on transcription of cytokines mRNAs in tarsal joint of SPF chickens[J]. Acta Veterinaria et Zootechnica Sinica, 2014,45(9):1505-1511. (in Chinese)
[34] SHERRY B. Rotavirus and reovirus modulation of the interferon response[J]. J Interferon Cytokine Res, 2009,29(9):559-567.
[35] ANAFU A A, BOWEN C H, CHIN C R, et al. Interferon-inducible transmembrane protein 3(IFITM3) restricts reovirus cell entry[J]. J Biol Chem, 2013, 288(24):17261-17271.
[36] MARTINEZ-COSTAS J, GONZÁLEZ-LÍPEZ C, VAKHARIA V N, et al. Possible involvement of the double-stranded RNA-binding core protein sigmaA in the resistance of avian reovirus to interferon[J]. J Virol, 2000, 74(3):1124-1131.
[37] GONZÁLEZ-LÍPEZ C, MARTINEZ-COSTAS J, ESTEBAN M, et al. Evidence that avian reovirus sigmaA protein is an inhibitor of the double-stranded RNA-dependent protein kinase[J]. J Gen Virol, 2003, 84(Pt6):1629-1639.
[38] LOSTALÉ-SEIJO I, MARTINEZ-COSTAS J, BENAVENTE J. Response of three different viruses to interferon priming and dithiothreitol treatment of avian cells[J]. J Virol, 2016, 90(18):8328-8340.
[39] LIN P Y, LIU H J, CHANG C D, et al. Avian reovirus S1133-induced DNA damage signaling and subsequent apoptosis in cultured cells and in chickens[J]. Arch Virol, 2011, 156(11):1917-1929.
[40] WU H, HE Z, TANG J, et al. A critical role of LAMP-1 in avian reovirus P10 degradation associated with inhibition of apoptosis and virus release[J]. Arch Virol, 2016, 161(4):899-911.
[41] CHI P I, HUANG W R, LAI I H, et al. The p17 nonstructural protein of avian reovirus triggers autophagy enhancing virus replication via activation of phosphatase and tensin deleted on chromosome 10(PTEN) and AMP-activated protein kinase (AMPK), as well as dsRNA-dependent protein kinase (PKR)/eIF2alpha signaling pathways[J]. J Biol Chem, 2013, 288(5):3571-3584.
[42] LI C, WEI H, YU L, et al. Nuclear localization of the p17 protein of avian reovirus is correlated with autophagy induction and an increase in viral replication[J]. Arch Virol, 2015, 160(12):3001-3010.
[43] CHEN Z, LUO G, WANG Q, et al. Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons[J]. Vet Microbiol, 2015, 175(2-4):232-243.
[44] 赵赫. TLR3与RIG-I相关信号分子在鸭呼肠孤病毒感染雏鸭免疫器官中表达变化研究[D]. 武汉:华中农业大学, 2015.
ZHAO H. Research on expression of TLR3 and RIG-I related factors in immune organs of duckling infected by DRV[D]. Wuhan:Huazhong Agricultural University, 2015. (in Chinese)
[45] WANG Q, WU Y, CAI Y, et al. Spleen Transcriptome profile of muscovy ducklings in response to infection with muscovy duck reovirus[J]. Avian Dis, 2015,59(2):282-290.
[46] 王全溪, 吴宝成, 李国平, 等. 番鸭呼肠孤病毒感染对体液免疫功能的影响[J].中国农业科学, 2010, 43(2):424-429.
WANG Q X, WU B C, LI G P, et al. Effects of duck infected by muscovy duck reovirus on humoral immunity function[J]. Scientia Agricultura Sinica, 2010, 43(2):424-429. (in Chinese)
[47] 黄丽娜,姜慧慧,王洁, 等.猴头菇多糖对呼肠孤病毒感染番鸭肠道黏膜免疫及抗氧化能力的影响[J]. 畜牧兽医学报, 2015, 46(9):1671-1677.
HUANG L N,JIANG H H,WANG J,et al. Effects of Hericium erinaceus polysaccharide on intestinal mucosal immune and antioxidant capacity of muscovy ducks infected with reovirus[J]. Acta Veterinaria et Zootechnica Sinica, 2015, 46(9):1671-1677. (in Chinese)
[48] 郑玲红, 吴异健, 廖加磊, 等.猴头菇多糖对MDRV感染番鸭血清中细胞因子及激素水平的影响[J]. 中国兽医科学, 2017, 47(2):249-256.
ZHENG L H, WU Y J, LIAO J L, et al. Effect of hericium polysaccharide on partial cytokines and hormones in muscovy ducks infected with muscovy duck reovirus[J]. Chinese Veterinary Science, 2017,47(2):249-256. (in Chinese)
[49] 马春全, 卢玉葵, 陈少莺, 等. 番鸭呼肠孤病毒感染番鸭血清中TNF-α和β-EP水平变化[J]. 畜牧与兽医, 2009, 41(5):74-75.
MA C Q, LU Y K, CHEN S Y, et al. Changes of TNF-α and β-EP levels in the serum of muscovy ducks infected with muscovy duck reovirus[J]. Animal Husbandry & Veterinary Medicine, 2009, 41(5):74-75.(in Chinese)
[50] GENG H, ZHANG Y, LIU-PARTANEN Y, et al. Apoptosis induced by duck reovirus p10.8 protein in primary duck embryonated fibroblast and Vero E6 cells[J]. Avian Dis, 2009, 53(3):434-440.
[51] WU Y, CUI L, ZHU E, et al. Muscovy duck reovirus sigmaNS protein triggers autophagy enhancing virus replication[J]. Virol J, 2017, 14(1):53.
[52] ZHANG M, SONG K, LI C, et al. Molecular cloning of Peking duck Toll-like receptor 3(duTLR3) gene and its responses to reovirus infection[J]. Virol J, 2015,12:207.
[53] MONTGOMERY R D, VILLEGAS P, DAWE D L, et al. A comparison between the effect of an avian reovirus and infectious bursal disease virus on selected aspects of the immune system of the chicken[J]. Avian Dis, 1986, 30(2):298-308.
[54] LIN H Y, CHUANG S T, CHEN Y T, et al. Avian reovirus-induced apoptosis related to tissue injury[J]. Avian Pathol, 2007, 36(2):155-159.
[55] 张昆丽. 禽呼肠孤病毒感染对体外细胞和SPF鸡细胞因子mRNA转录影响的初步研究[D]. 南宁:广西大学, 2014.
ZHANG K L. A preliminary research on the influence of avian reovirus infection on cytokines mRNA transcription in vitro and in SPF chickens[D]. Nanning:Guangxi University, 2014. (in Chinese)
[56] 林锋强, 陈少莺, 朱小丽, 等. 番鸭呼肠孤病毒和H9亚型禽流感病毒共感染对番鸭法氏囊和抗体产生的影响[J]. 中国预防兽医学报, 2012,34(2):133-137.
LIN F Q, CHEN S Y, ZHU X L, et al. Influence of co-infection with muscovy duck reovirus and H9 avian influenza virus on bursa and antibody response in muscovy ducks[J]. Chinese Journal of Preventive Veterinary Medicine, 2012, 34(2):133-137. (in Chinese)
[57] 王全溪, 赵丽娟, 苏凤, 等. 番鸭呼肠孤病毒B3株感染对雏番鸭细胞免疫功能的影响[J]. 福建农林大学学报(自然科学版), 2009,38(4):380-383.
WANG Q X, ZHAO L J, SU F, et al. Effects of infection with muscovy duck reovirus isolate B3 on the cellular immunity function of muscovy duck[J]. Journal of Fujian Agriculture and Forestry University (Natural Science Edition), 2009, 38(4):380-383. (in Chinese)
[58] MEANGER J, WICKRAMASINGHE R, ENRIQUEZ C E, et al. Immune response to avian reovirus in chickens and protection against experimental infection[J]. Aust Vet J, 1997, 75(6):428-432.
[59] 林锋强, 陈仕龙, 陈少莺, 等. 番鸭呼肠孤病毒病活疫苗诱导的免疫应答分析[J].畜牧兽医学报, 2011,42(12):1800-1804.
LIN F Q, CHEN S L, CHEN S Y, et al. The study on immunne response of muscovy duck reovirusis alive vaccine[J]. Acta Veterinaria et Zootechnica Sinica, 2011, 42(12):1800-1804. (in Chinese)
[60] LE GALL-RECULÉ G, CHERBONNEL M, ARNAULD C, et al. Molecular characterization and expression of the S3 gene of muscovy duck reovirus strain 89026[J]. J Gen Virol, 1999,80(Pt1):195-203.
[61] WICKRAMASINGHE R, MEANGER J, ENRIQUEZ C E, et al. Avian reovirus proteins associated with neutralization of virus infectivity[J]. Virology, 1993, 194(2):688-696.
[62] KUNTZ-SIMON G, LE GALL-RECULÉ G, DE BOISSÉSON C, et al. Muscovy duck reovirus sigmaC protein is atypically encoded by the smallest genome segment[J]. J Gen Virol, 2002, 83(Pt5):1189-1200.
[63] ZHU Y, LI C, BI Z, et al. Protective immune responses in ducklings induced by a suicidal DNA vaccine of the sigma C gene of novel duck reovirus[J]. Vet Immunol Immunopathol, 2015, 165(1-2):88-92.
[64] YIN C H, QIN L T, SUN M Y, et al. Antigenic analysis of monoclonal antibodies against different epitopes of sigmaB protein of avian reovirus[J]. PLoS One, 2013, 8(11):e81533.
[65] YIN C H, QIN L T, SUN M Y, et al. Identification of a linear B-Cell epitope on avian reovirus protein sigmaC[J]. Virus Res, 2013, 178(2):530-534.
[66] GOLDENBERG D, LUBLIN A, ROSENBLUTH E, et al. Optimized polypeptide for a subunit vaccine against avian reovirus[J]. Vaccine, 2016, 34(27):3178-3183.
[67] LIU M, CHEN X, WANG Y, et al. Characterization of monoclonal antibodies against Muscovy duck reovirus sigmaB protein[J/OL]. Virol J, 2010, 7:133.[2017-09-30]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907335/